Translation of "Arterial occlusion" in German

Iclusig should be interrupted immediately in case of arterial occlusion.

However, surgical procedures are often required to resolve the arterial occlusion.

It helps with rheumatoid arthritis and peripheral arterial occlusion .

Factors other than dose may also contribute to this risk of arterial occlusion.

Peripheral arterial occlusion disease is diagnosed on the basis of the typical symptoms and with various examinations.

Arterial occlusion adverse events were more frequent with increasing age and in patients with history of ischaemia, hypertension, diabetes, or hyperlipidaemia.

The interruption in blood circulation can occur due to tourniquets or ligature clamps, for example in order to obtain a blood-free operating field, and due to arterial or venous occlusion or blockage caused by embolic or thrombotic obstructions in blood vessels.

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H2 receptors and in part also due to their additional H1 -antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.

BACKGROUND OF THE INVENTION The present invention relates to new imidazolyl guanidine derivatives which by virtue of their agonistic action on histamine-H2 receptors and in part also their additional H1 -antagonistic receptor activity may be used in cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.

This invention relates to new compounds which act on the cardiac circulation and in particular 1,4-dihydropyridines which manifest calcium antagonistic and/or H2 -receptor agonistic activities and are therefore eminently suitable for use in cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.

Examples of indications are therefore tendinose, condylopathy, torticollis, restless legs, Sudeck syndrome, Raynaud disease, Buerger disease, diabetic angiopathy, a tendency towards muscle cramp, more specifically of the calf musculature, and arterial occlusion diseases.

Other thrombotic occlusion diseases which require treatment include pulmonary embolism, venous thrombosis and peripheral arterial occlusion diseases.

From 0.1 to 1 mg of a polypeptide according to the invention is required per kg for the treatment of vascular occlusions caused by thrombosis, for example coronary thrombosis, cerebral thrombosis, peripheral acute arterial occlusion, pulmonary embolism, unstable angina pectoris and deep venous thrombosis of the legs and pelvis.

An occluding body suitable for the intra-arterial and intravenous occlusion of blood vessels, is known from DD-A-158 084, in which occluding body a wire spiral is formed, with the use of relatively high degrees of deformation, into a helical spring body, such that the spring body, on the application of an external force, can be elastically reformed into a straight wire spiral and, on partial cessation of this force, assumes a knot-shaped configuration.

Measurement of the viscoelastic flow properties of blood is used as the most modern method of determining pathological changes in erythrocytes in clinical haemorheology (for example in arterial occlusion, stroke and generally in peripheral circulatory disorders).

In view of their pharmacological properties, the compounds of general formula I prepared according to the invention and their optically active antipodes and physiologically acceptable acid addition salts with inorganic or organic acids are suitable for the treatment of chronic and acute cardiac insufficiency of various origins and/or for the prevention of arterial thromboembolism and diseases of arterial occlusion.

The present invention relates to new imidazolyl guanidine derivatives which by virtue of their agonistic action on histamine-H2 receptors and in part also their additional H1 -antagonistic receptor activity may be used in cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.

To facilitate on-pump cardiac surgery procedures through smaller incisions, Edwards also offers a cardiac surgery product line comprising soft tissue retractors, venous and arterial cannulae, aortic occlusion, venting, and coronary sinus catheters, as well as reusable instruments for performing minimally invasive valvular procedures.

Arterial occlusion disease of the pelvic and femoral arteries, hip arthrosis, gynecological processes and sacroiliac processes may also involve similar symptoms.

The limitation of the thrombotic potential of an already existing clot is a critical point in the prevention of arterial occlusion.

The compounds of the formula I are furthermore suitable for the prevention and treatment of late damage in diabetes, such as, for example, nephropathy, retinopathy, neuropathy and syndrome X, obesity, cardiac infarction, myocardial infarction, peripheral arterial occlusion diseases, thromboses, arteriosclerosis, inflammation, immune diseases, autoimmune diseases, such as, for example, AIDS, asthma, osteoporosis, cancer, psoriasis, Alzheimer's, schizophrenia and infectious diseases, preferably the treatment of type 1 and type 2 diabetes and for the prevention and treatment 15 of late damage in diabetes, syndrome X and obesity.

Therefore it can be assumed that a clear increase of the therapeutic benefit for the known indications of moxaverin, such as peripheral arterial or coronary occlusion disease, vascular-related dementia, etc., can be achieved.

For the purpose of the present invention, “thromboembolic disorders” include, in particular, serious disorders such as myocardial infarct, angina pectoris (including unstable angina), reocclusions and restenoses after angioplasty or aortocoronary bypass, stroke, transitory ischaemic attacks, peripheral arterial occlusion disorders, pulmonary embolisms or deep venous thromboses.