Translation of "Borna disease" in German

Bornaviruses cause a lethal form of encephalitis, called Borna disease, among horses and sheep.

This virus triggers the co-called Borna disease in mammals and the proventricular dilatation disease in birds.

Clinical signs of Borna disease among horses and sheep include behavioural disturbances and disorientation.

Animals suffering from Borna disease develop motor and behavioural disorders.

Summary Borna disease virus (BDV) is considered to be the prototype of a new family of coated negative-strand RNA viruses.

The first indication of a possible outbreak of Borna disease came from two vigilant local veterinarians.

Recently, the Applicants were able to find virus proteins and genetic material of the Borna disease virus (BDV) in the blood samples of emotionally sick patients during an acute depressive phase. This genetic material comprised sheathed, non-segmented, single-strand RNA virus of negative polarity, which is known to initiate emotional and, in some cases, depression-like symptoms in animals.

Water-soluble derivatives of L-adamantane amines inhibit the infection with Borna disease virus (in vitro, to the extent of 80%) and prevent virus replication in the already infected cells.

The encephalitis which is termed the so-called classic Borna disease is probably caused by a virus production which has gone out of control.

The invention allows Borna disease virus (BDV) infections in humans and animals to be identified virtually completely by combining a newly-discovered assay parameter, CICs in the blood plasma, with parameters which are already known, viz. AG in leukocytes or blood plasma and Ab in the plasma.

In an assay cited in the examples (see “Ab assay”), for example, a dilution of a 10% brain suspension of a horse which had died from Borna disease was used.

To achieve this object, the invention provides a process for detecting Borna disease virus (BDV) infection, in which immune complexes of BDV antigens and specific antibodies attached thereto, which circulate freely in the body fluid, are detected in a body fluid specimen to be tested by means of a suitable immunological assay.

Specimen 4311 was obtained from a horse from Northern Germany (initial G.) which had been examined in March 1997 owing to the (questionable) clinical diagnosis “Borna disease.

Specimen 5231 was obtained from a horse from Southern Germany (initial D.) which had been examined in May 1997 owing to the clinical diagnosis Borna disease.

Brain suspensions (10%) of horses which have died from Borna disease contain a high concentration of viral proteins (in particular N- and P-proteins).

Of substantial economic importance are also infections caused by the Borna disease virus (BDV), in particular those that attack horses and sheep, which have been isolated in man, too, and which have been connected with neurological diseases.

Newer data show that the inhibition of the Ras-Raf-MEK-ERK signal transduction pathway or of another signal transduction pathway, the MEKK/SEK/JNK signal transduction pathway, can drastically inhibit by active ingredients, which relatively selectively inhibit one of the kinases involved in this signal transduction pathway, for instance the MEK or the SEK, the intracellular multiplication of intranuclearly replicating negative-strand viruses, for instance of influenza A viruses and the Borna disease virus (BDV) (Pleschka et al., Nature Cell Biol 3, 301-305, 2001;

An endemic area of the Borna disease, which is a lethal encephalitis in horse and sheep, was recently discovered in Austria for the first time.

Link to press release "Regional "hot spot" of Borna disease discovered in Upper Austria", the scientific article and free press photo.

The Borna disease – named after the German city of Borna, which saw a cluster of cases over 100 years ago – mainly affects horses and sheep, and in rare cases cattle and rabbits too.