Translation of "Hyperinsulinism" in German

A drop in blood sugar is associated with hyperinsulinism.

Hyperinsulinism is definitely the functional cause of weight gain!

In men, hyperinsulinism is accompanied by a drop in total and free testosterone.

It has surprisingly been found according to the invention that a morphological correlate exists for hyperinsulinism.

This then becomes a vicious circle where hyperinsulinism ensues in insulinoresistance.

That spontaneous hyperinsulinism might be a cause of symptomatic hypoglycemia was first proposed by Seale Harris, MD, 1924, in Journal of the American Medical Association.

High blood pressure, obesity, diabetes, hyperinsulinism, non-alcoholic fatty liver disease, fructose malabsorption, gout, hyperuricaemia, breast cancer and renal diseases can either directly or indirectly be caused by the ingestion of huge amounts of the fructose.

Of interest to us primarily is not the increase in blood sugar levels (cf. glycemic index), but rather the subsequent relative hypoglycemia as a sign of an existing hyperinsulinism, which leads to a heightened building of reserves.

The hyperinsulinism provoked by said hyperglycemia will, under the impulse of lipoprotein lipase, convert this residual glucose into fat which will be stored in fat cells.

In WO2005/004990, it was surprisingly discovered that there is a morphological correlation for hyperinsulinism.

W rats showed that a morphological correlate for hyperinsulinism could be found (see table 5 above).

Hyperinsulinism is the result of an excessive pancreatic secretion of the insulin hormone.

As a result of this inertia, our organism becomes «impatient» and orders our pancreas to secrete more insulin, that which only contributes to aggravating hyperinsulinism.

It can even be recommended to control weight during pregnancy and avoid risks of hyperinsulinism (high blood sugar levels) in the unborn infant.

Nowadays we know that these perverse metabolic effects have resulted in increased rates of hyperinsulinism which is at the root of obesity, diabetes and many cardiovascular illnesses which are prevalent in our societies.

In this way, it is possible to reduce or prevent hyperinsulinism, which is a risk factor in diabetes, obesity and certain cardiovascular illnesses.

In mutant form, this enzyme, encoded by the Glud1 gene, is responsible for a congenital hyperinsulinism syndrome, a severe disease affecting at the same time the endocrine pancreas, the liver and the brain.

Within the framework of his research on insulin secretion disorders, he maintains close cooperation with the University Children’s Hospital Düsseldorf. Here research focuses on the elucidation of hyperinsulinism in children. These children have a life-threatening disease characterized by severe hypoglycemia and seizures due to a congenital defect of the islets of Langerhans in the pancreas. However, with early diagnosis and the initiation of often complex treatment regimens, they can lead a relatively normal life.