Translation of "Infectiousness" in German

This loss of infectiousness can be explained by the loss of the capability to form attachments.

The vector particles according to the invention may also be purified without or without any substantial loss of infectiousness.

Vector particles cannot be purified without loss of infectiousness due to the instability of their envelope proteins.

The vector particles according to the invention can also be purified without or without any substantial loss of infectiousness.

The risk of contagion is in turn determined by the infectiousness of the pathogen and by the transmission route to people.

The recommendation by SEAC, the British scientific advisory committee, has resulted in new findings about the infectiousness of certain nervous tissue along the spinal column and of red bone marrow.

The detection of the anti-HBcAg antibody is thus proof of the infectiousness of the vaccine or blood product under investigation.

The virucidal agents of the present invention are so highly active that mostly within one minute (after a period of 15 minutes at the latest), the activity and infectiousness of the most frequent naked viruses are reduced by at least 4 powers of ten.

Investigations with polio virus 1 (Mahoney) in the suspension test show that after 1 to 5 minutes, the infectiousness is decreased by from 3 to 5 powers of ten.

On the basis of these results, it can thereby be derived that through infection of LC5-cells, the neutralizing properties of serums (reduction of infectiousness of HIV) can be assessed.

The invention thus furthermore relates to a process, which comprises heating a C1 inactivator-containing solution in the presence of stabilizers until the solution has lost its infectiousness caused by a content of hepatitis B virus.

In herpes viruses, the glycoproteins important for infectiousness are embedded in a phospholipid membrane derived from a nuclear membrane.

Compared with the amphotrophic virions, the infectiousness of MLV(LCMV) pseudotypes during ultracentrifugation was, however, more stable at least by a factor of 1000.

The infectiousness of an inoculum of unknown magnitude can consequently be calculated comparatively precisely from the number of oocysts produced (number of oocysts per g in the cecum).

All these inactivation methods aim at eliminating the potential infectiousness of the preparations, while maintaining their biological activity as far as possible.

This so-called pseudo-typing is particularly attractive for herpes virus vectors since the glycoproteins important for infectiousness are embedded into a phospholipid membrane derived from a nuclear membrane. This membrane is essentially unstructured and only loosely encapsulates the strictly geometrical capsid of the virion.

After 120 minutes, less than 0.02% of the employed SHV-1, BHV-1, and HSV-2 infectiousness could be detected.

With the viruses VSV and SIV agm, such a ratio of residual infectiousness was reached after an incubation period of only 60 minutes.

The effect of the concentration of cyclic lipopeptide on the inactivation efficiency may be quantified by determining the inactivation rate (decrease of virus infectiousness per inactivation time).

The effect of temperature on the virus inactivation during the inactivation reaction may be quantified by determining the inactivation rate (decrease of virus infectiousness per inactivation time).

Within a period of 5 minutes, the initial titer dropped from 1.6×10 5 TCID 50 to a residual infectiousness of 9 .

The object of the present invention is to provide a generally applicable process by which the virus population lose certain pathogenic properties, particularly the property of infectiousness.

This so-called pseudo-typing is particularly attractive for herpes virus vectors since the glycoproteins important for infectiousness are embedded into a phospholipid membrane derived from a nuclear membrane.

For a further control experiment, a negative plasma was admixed with a preparation of HIVIIIB, whose infectiousness had previously been determined in vitro.

As emerges from the results in Table 1, PI 3 virus is very rapidly inactivated by the high doses of BACI (0.1 mg/ml, 0.05 mg/ml), i.e. in the time which was needed to mix the virus-containing sample thoroughly with BACI, to take a sample and to titrate this in order to determine the infectiousness of PI 3 virus, infectious virus was no longer detectable.