Translation of "Off-target effects" in German

Thus, off-target effects or associated toxicities can be reduced.

But CRISPR can also cause so-called “off target” effects.

We also want to understand better how to control the way that DNA is repaired after it's cut, and also to figure out how to control and limit any kind of off-target, or unintended effects of using the technology.

Problems include “off-target” effects, where the DNA is also snipped at places it shouldn’t be, and “genetic mosaicism”, where the result has a mixture of modified and unmodified cells.

The constructs have been optimized to exclude low complexity regions and other sequence motifs that induce off-target effects.

It is very important to confirm whether He Jiankui really did eliminate the mosaic and the off-target effects.

However, the latest research shows that there can often be unintended impacts – known as off-target effects – on the genome.

The group strongly focuses on computer-aided prediction of off-target effects as well as the identification of novel 'toxicophores' and toxicity targets (targets associated with adverse drug reactions) using ligand- as well as protein-based structural and physicochemical information.

Overall, based on trial data so far, we see obvious issues with these gene-based drugs both with regard to their initial effectiveness, durability and specifically the cumulative off-target side-effects resulting from having to take them on a never stop basis.

In order to avoid such so-called off-target effects, the researchers are currently testing coated stents or balloons that are inserted directly into the carotid artery in pigs.

And how can we prevent unwanted, "off-target" effects that may, for example, modify genes that were not supposed to be modified and could cause cancer?

For the correct assessment of phenotypes, a key issue remains the stringent quality control of long double-stranded RNAs (dsRNA) to calculate potential off-target effects that may obscure the phenotypic data.

When selecting the target genes for HIGS strategies, with a view to applicability, it is vital that it has as short as possible or preferably no homologies extending over more than 17 sequential base pairs to the gene sequences of non-target organisms, as if there were, gene expression of the non-target organisms in the case of consumption of the transgenic plant or its harvest product could be destroyed (“off-target” effect).