Translation of "Ph shift" in German

When the sample causes a pH shift to the acid range, buffering can be accomplished with solvent and imadazole.

In particular, the decomposition speed of a degradable metal stent main body may be negatively influenced by the pH value shift into the acid range.

Potassium phosphate buffers in contrast to sodium phosphate buffers have only a slight pH shift (preferably at most ±1 pH unit, particularly preferably at most ±0.5 pH units) during the freezing process.

The partial neutralization in stage C, as well as the pH shift in stage F, is effected by adding bases, preferably using alkali metal hydroxides such as NaOH and ammonia, normally as aqueous solution.

For achieving the conditions according to the invention it is not of significance whether the anti-D IgG fraction is eluted by increasing the ionic concentration, or by pH shift or by a buffer changed in composition.

The methods according to Examples 1 to 4 are repeated, whereby the IgG fraction containing anti-D is eluted from the MacroPrepR 50 CM gel (BioRad, Hercules Calif., USA) alternatively with 0.1M glycine+0.5M sodium chloride, pH 9, or generally with pH shift and/or change of the ionic strength and/or other changes in the buffer composition, instead of with 25 mM sodium phosphate buffer+0.2M sodium chloride, pH 7.5, analogous results being obtained.

The method of claim 1 or 2, wherein the elution in step (b) is carried out with a pH shift and/or a change of the buffer composition.

In this connection, the CO 2 diffusing into the water-impregnated layer leads to a chemical reaction with pH-shift.

In addition, a pH shift occurs, and chlorine and hypochlorite remain in the treated liquid, so that a reinfusion with this liquid cannot be performed.

Likewise, recovery of nontarget fractions after further rearrangements or reactions, such as, for example, re-racemization by means of pH or temperature shift, are more efficiently possible in the feed mixture or the reactor.

Another very simple system is based on the detection of a pH shift during the microbial contamination (IE 20060034).

As already described, therefore, it is particularly advantageous to set current densities in the range of 0.5 to 4 A/dm 2 in the method according to the invention to ensure low corrosion of the tin coating on the one hand while on the other hand producing an adequate pH shift directly at the tin surface which is sufficient to precipitate dissolved silicate as SiO 2, thus causing silicating of the surface.

Use of such medicaments on degradable stents results in the additional advantage that the chemical action of decomposition products of the base body (for example, OH ? ions for Mg or H + ions for PLLA) on the medicament and the elution of medicament is suitably reduced in such a way that a sufficient, effective quantity of the medicament is eluted, and the medicament is not destroyed, or its activity is not appreciably impaired, as a result of the degradation-related pH shift or other chemical processes occurring during degradation.

Hence, a pH shift caused by the out-gassing and in particularly by the out-gassing of CO 2 and, hence, undesired precipitations of calcium-carbonate and other chemical compounds from the flowing solution may be avoided.

In this final pH shift from the acidic to the less acidic range to the neutral range, the dissolved phytic acid precipitates out as phytate and can thus be separated from the fluid, for example by centrifuging, gravitation, or filtration.

On a draining of the liquid by the lowering of the liquid level and the accompanying increase in size of the gas space above the medical liquid, the physical marginal conditions of the chemical-physical equilibrium between the liquid and the gas space change which, in the known method described above, results in the pH shift which then subsequently has to be corrected.

A further advantage is that, as a result of the partial degradation of the organic acids which arise during the hydrolysis 2, a sufficient pH shift already takes place.

Preferably, separation of the framework material solid is achieved via solid-liquid separation, centrifugation, extraction, filtration, membrane filtration, cross-flow filtration, diafiltration, ultrafiltration, flocculation with the use of flocculation aids such as e.g. nonionic, cationic and/or anionic aids, pH shift by adding additives such as e.g. salts, acids or bases, flotation, spray-drying, spray granulation or evaporation of the mother liquor at elevated temperatures or reduced pressure and concentration of the solid.

The framework solid is preferably separated off by solid-liquid separation, centrifugation, extraction, filtration, membrane filtration, crossflow filtration, diafiltration, ultrafiltration, flocculation using flocculants such as nonionic, cationic and/or anionic auxiliaries, pH shift by addition of additives such as salts, acids or bases, flotation, spray drying, spray granulation or evaporation of the mother liquor at elevated temperatures and/or under reduced pressure and concentration of the solid.

In the case of coacervation, the microcapsules are produced in a colloidal system, wherein the precipitation is initiated for example by a suitable pH shift.

The reversibly immobilized solvent is in an evaporated aggregate state and assumes the liquid state by physico-chemical changes, such as pH shift, change of mole fraction and the temperature in its volatility and/or in its vapor pressure (which can be compared to vapor as a solvent in its non-immobilized form and water as a reversibly immobilizable solvent).