Translation of "Dermatika" in English

Achim Zesch, BfArM informed about problems in the authorization of dermatics.

Formulations, skincare products or dermatological preparations according to the invention advantageously comprise the following combinations:

As a consequence, their use is limited to a few cosmetics and products for dermal use.

Thus a placebo for dermatics can virtually not be defined.

It has taken over all dermatics from Schering Deutschland AG (Schering Germany Corporation).

Some dermatics are for example admitted for the interval therapy.

As dermatics, hyaluronan-containing gel imfungi are used for correcting skin deformations in plastic surgery.

When considering the prices of different dermatics as example this connection becomes clear (table 1).

Furthermore it must be considered, that the water content after dermal application will change.

In his function of dermatologist Zesch equally went into the special features which have to be considered for the authorization of topical dermatics.

For the processing of essential fatty acids in cosmetic and dermatic products it is recommended to use as little additives as possible.

It is expressly emphasized that current developments in view of scientific assessment of dermatics are taken up promptly.

The same considerations apply to systemical dermatics in the given context as to other systemical drugs.

As components building up the fatty phase, the fatty phase components customary for the pharmaceutical forms according to the invention (ointments, pastes emulsions and especially creams) can be used, and especially the components customary for the preparation of dermatics.

In "Pharmazeutische Technologie" [Pharmaceutical Technology], published by Sucker, Fuchs and Speiser, Stuttgart, 1978, pp. 305-310, cholesterol is mentioned as an emulsifier in dermatological products.

Important examples of groups and individual substances, without any claim to completeness, are the following: analgesics, anti-allergics, anti-arrhythmics, antibiotics, chemotherapeutics, antidiabetics, antidotes, anti-epileptics, antihypertensives, antihypotensives, anticoagulants, antimycotics, antiphlogistics, beta receptor blockers, calcium antagonists, and ACE inhibitors, broncholytics/anti-asthmatics, cholinergics, corticoids (internal), dermatics, diuretics, enzyme inhibitors, enzyme preparations, and transport proteins, expectorants, geriatrics, gout medications, flu medications, hormones and their inhibitors, hypnotics/sedatives, cardiac medications, lipid lowering agents, parathyroid hormone/calcium metabolism regulators, psychopharmaceuticals, sex hormones and their inhibitors, spasmolytics, sympathomimetics, vitamins, would treatment medications, cytostatics.

It is also possible to discharge lotions, which represent a special preparation form inter alia for cosmetics and dermatics.

As a particular embodiment, the present invention relates to the use of microemulsion gels according to the invention for medical purposes, in particular as medicament carriers for lipophilic active compounds and their pharmaceutical use as topical dermatological agents, but also for the parenteral administration of pharmaceutical active compounds and for parenteral nutrition.

A physician is therefore forced to continue his/her treatment and to resort to dermatics, antibiotics and antimycotics (with secondary infections allergy-damaged skin parts), i.e., to drugs which contain chloramphenicol, rifampicin, flumethasone, dexamethasone, triamincinolonacetonide or hydrocortisone, just to mention a few.

For use, the active compound combinations according to the invention or the cosmetic or dermatological formulations according to the invention are applied to the skin and/or hair in an adequate amount in the manner customary for cosmetics and dermatological agents.

For use, the thiols or thiol derivatives according to the invention are applied to the skin and/or hair in an adequate amount in the manner customary for cosmetics and dermatological agents.

For application in the usual way for cosmetics and dermatics, the preparations according to the invention are applied in sufficient amount on the skin and/or the hair.

For use, the cosmetic and dermatological preparations according to the invention are applied to the skin and/or hair in a sufficient amount in a manner customary for cosmetics or dermatological compositions.

Besides water and oils hardly any other substance group is as widely used in skin care products and dermatics as polyethylene glycols and their related substances. Interesting things to know are compiled in the following article.

Thus, more and more cosmeticians seek information on dermatology, dermatologists deal with cosmetics and pharmacists improve their sales competence in dermatics and cosmetic.

As the example in table 2 shows, the price advantages frequently asserted in the field of non-prescription dermatics which often serve as argument for cost effectiveness in comparison to comparable ready-to-use drugs have decreased respectively are no longer existent.

Dossiers for medication (dermatological medication) are developed, tested and authorised in accordance with international ICH guidelines and in compliance with GMP and GCP regulations by the appropriate authorities.