Übersetzung für "Rimantadine" in Deutsch

Examples of virostatics include amantadine and rimantadine.

No pharmacokinetic interactions between oseltamivir or its major metabolite have been observed when co-administering oseltamivir with paracetamol, acetylsalicylic acid, cimetidine, antacids (magnesium and aluminium hydroxides and calcium carbonates), rimantadine or warfarin (in subjects stable on warfarin and without influenza).

For patients with renal insufficiency, preferably rimantadine is indicated, because it is metabolized in the liver and therefore the clearance of the drug does not depend on the function of the kidneys.

The principles of action of all of the former antiviral agents (except for active and passive immunization and support of the immune defense by endogenous substances, such as interleukins and interferons as well as amantadine and rimantadine whose mechanism of action is not precisely known yet) are based on an inhibition of virus-specific enzymes (polymerases), for instance, on the inhibition of the viral DNA or RNA synthesis by nucleoside analogues (9).

The hematological toxicity, which in the case or interferon a1 depends on the dose (threshold dose 3×106 units/ml), does not manifest itself with these pharmaceutical preparations for mercury cyanide, rimantadine, amantadine and ribavirin.

Here too it has surprisingly been found that rimantadine micellarly included in a cationic tenside, in particular of the two above formulae, has the same in vitro effect as the pure pharmaceutical active substance although with a substantially smaller dose of 0.05 ?g/ml.

Here too it has suprisingly been found that rimantadine micellarly included in a cationic tenside, in particular of the two above formulae, has the same in vitro effect as the pure pharmaceutical active substance although with a substantially smaller dose of 0.05 ?g/ml.

The hematological toxicity, which in the case of interferon a1 depends on the dose (threshold dose 3×106 units/ml), does not manifest itself with these pharmaceutical preparations for mercury cyanide, rimantadine, amantadine and ribavirin.

Here too it has surprisingly been found that rimantadine micellarly included in a cationic tenside, in particular of the two above formulae, has the same in vitro effect as the pure pharmaceutical active substance although with a substantially smaller doseof 0.05 ?g/ml.

Currently, four pharmaceutical drugs are recommended for flu treatment and to prevent virus infections: the adamantanes (Amantadine and Rimantadine) and a newer class of neuraminidase inhibitors (zanamivir – Relenza, and oseltamivir – Tamiflu).

Other uses for this drug include using it together with rimantadine as a treatment for influenza, or for the relief of pain during an endometrial or hysteroscopy biopsy.

The viruses so far characterized have been sensitive to oseltamivir, but resistant to both amantadine and rimantadine.

Among them, ribavirin, although has antiviral activity on influenza virus A and B at high doses but have teratogenic and mutagenic toxicity like nucleoside drugs and can cause anemia and immune suppression while amantadine and rimantadine are only effective in treating influenza A and is easy to cause central nervous system toxicity, thereby reducing the clinical value.

To the further antivirally acting active ingredients in the combination preparation according to the invention belong either at least one further active ingredient according to the invention and/or at least one antiviral active ingredient, such as: amantadine (1-adamantanamine) and its derivatives, which is or are directed against a transmembrane protein of some influenza A viruses, such as rimantadine, therapeutic agents for influenza infections inhibiting the influenza-viral surface protein neuraminidase.